DOI: 10.36347/sajp

Pages: 274-281

The purpose of this research is to prepare amlodipine immediate release tablets by direct compretion method. In order to obtain the best, optimized product four different formulations were developed. Different super disintegrants, binding agents and lubricant were taken as variables. Weight variation, thickness, hardness, friability, disintegration time, in-vitro release and pharmaceutical assay were studied as response variables. Capping was observed in formulation containing PVP K-30.The formulation F4 was selected as optimized formulation. The different physical properties and in-vitro release profile showed best results with the reference product.