DOI: 10.36347/sajp

Pages: 289-292

4-thiazolidinone and their derivatives were possessed a wide range of pharmacological activities such as antiinflamatory , analgesic, anticonvulsant, antimicrobial (antibacterial and antifungal), local and spinal anaesthetics, CNS stimulants, hypnotics, anti HIV, hypoglycemic, anticancer, FSH receptor agonist and CFTR inhibitor etc. The objective of the present work is to synthesize N-[2-(4-substituted phenyl)-4-oxo-1, 3-thiazoldine-3-yl]-2-(naphthalene-2- yloxy) acetamide and evaluate for antidepressant activities by forced swim and tail suspension test. Three compounds were synthesized and they were characterized by FT-IR, 1H-NMR and Mass Spectral studies. The determination of melting point, solubility studies were carried out. Imipramine was used as the standard drug. Two of the synthesized compounds V1 and V3 were found to be significant in Forced Swim Test, while only compound V1 was found to be significant in Tail suspension test when compared with the standard drug Imipramine