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Scholars Academic Journal of Pharmacy | Volume-2 | Issue-04
Development and validation of UV-Method for simultaneous estimation of Artesunate and Mefloquine hydrochloride in bulk and marketed formulation
Akshay D. Sapakal, K. A.Wadkar, S. K. Mohite, C. S. Magdum
Published: April 30, 2013 |
213
145
DOI: 10.36347/sajp
Pages: 293-297
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Abstract
A simple, accurate, precise and economical Uv-method for estimation of Artesunate and Mefloquine HCL was
developed. For analysis of Artesunate and Mefloquine HCl, 242nm and 256nm wavelengths were used respectively. The
linearity range for Artesunate and Mefloquine HCl were 20-140µg/ml & 50-350µg/ml. Results of analysis were validated
statistically, recovery studies for ART were 98.33-100.33 & for MEF 101.33-101.92. The LOD and LOQ were found to
be 0.13μg/ml and 0.39μg/ml for ART. For MEF the LOD and LOQ values were found to be 1.53µg/ml & 2.21µg/ml the
method was validated as per ICH guidelines.