DOI: 10.36347/sajp

Pages: 293-297

A simple, accurate, precise and economical Uv-method for estimation of Artesunate and Mefloquine HCL was developed. For analysis of Artesunate and Mefloquine HCl, 242nm and 256nm wavelengths were used respectively. The linearity range for Artesunate and Mefloquine HCl were 20-140µg/ml & 50-350µg/ml. Results of analysis were validated statistically, recovery studies for ART were 98.33-100.33 & for MEF 101.33-101.92. The LOD and LOQ were found to be 0.13μg/ml and 0.39μg/ml for ART. For MEF the LOD and LOQ values were found to be 1.53µg/ml & 2.21µg/ml the method was validated as per ICH guidelines.