DOI: 10.36347/sjams.2019.v07i12.049

Pages: 4077-4079

Background: Cervical cytology is the cornerstone of cervical screening programmes. Its use in detecting cervical cancer cases at early stages has cemented it’s role and improved outcomes in these patients. The long pre-invasive period of the disease makes it possible to detect it early and hence, curtail it’s complications. Aim: To correlate the results of liquid based cytology with colposcopy guided biopsy results in women with unhealthy cervix and establish it’s efficacy in screening pre-malignant lesions of cervix. Study Design: A prospective, clinical study. Materials and Methods: All 121 women, between ages 21 to 65 years, with unhealthy cervix on per speculum examination,were subjected to Pap smear with liquid based cytology followed by colposcopic evaluation and guided biopsy. Following this the cytology results were compared with biopsy results. Women less than 21 years, more than 65 years, frank cases of carcinoma and mensurating women were excluded. The women presented to the Gynecological OPD with complaints of vaginal discharge, inter-menstrual bleed, pain abdomen, post-coital bleeding etc. Results: Sensitivity and specificity of liquid based cytology in our study was found to be 88.88% and 89.32%. Positive predictive value was 59.25% and negative predictive value was 97.87%. Accuracy was found to be 97.87%. This showed that liquid based cytology as a sensitive tool for detecting pre-malignant lesions of the cervix. Conclusion: The present study establishes the role of liquid based cytology as a screening modality for carcinoma cervix. Combination of cytology with colposcopy improves the rate of detection of carcinoma cervix in early stages.