DOI: 10.36347/sajp

Pages: 315-318

This article to investigate the effectiveness of using Niosomes in a transdermal drug delivery system for Econazole. Topically applied Niosomes can increase the longer action on the skin (stratum corneum and epidermis), while reducing the systemic absorption of the drug. Econazole is a imidazole antifungal agent used in the treatment of Candida infections, fungal infections. Econazole Niosome was prepared by Thin Film Hydration Technique by varying the cholesterol and surfactant ratios as 1:1, 1:2, 1:3, 1:4 Each formulation was evaluated for drug release. The release showing required amount of drug release per day as well as extended for the required day is the optimized formulation. Hence, B formulation is the optimized one