DOI: 10.36347/sjams.2019.v07i03.062

Pages: 1182-1186

Premature ejaculation is the most common male sexual disorder causing psychological distress for both partners and diminished quality of life. With the advent of selective serotonin reuptake inhibitor causing delayed ejaculation and their subsequent use in treatment of premature ejaculation, it is now the cornerstone of drug therapy in premature ejaculation. In the past, both on demand and daily dosing of multiple drugs have been studied. However, their efficacy and side effect has not been studied comparatively. In our study, patients with premature ejaculation with intravaginal ejaculation latency time (IELT) of less than 60 seconds were included. Patients with known history of substance abuse were excluded. Patient and their partner were taught to measure IELT with a stopwatch. Thirty patients were given on demand 30mg dapoxetine and another thirty patients were given 20mg daily dose of paroxetine. They were called up after four weeks and increase in IELT and side effects were recorded. After 4 weeks, mean increase in IELT in the dapoxetine group was 57.06 seconds while in paroxetine group was 64.5 seconds. The mean increase in IELT was more in daily dose paroxetine was more and it was statistically significant. Side effect profile was similar in both groups with daily dosing group experiencing slightly more side effects. Nausea headache and diarrhea were the most common side effects. Anejaculation and loss of libido were rare but serious side effects. Both dapoxetine and paroxetine are effective drugs for premature ejaculation and they have been shown to increase IELT in daily or on-demand dosing. It was shown that daily dosing paroxetine was more effective than on-demand dosing of dapoxetine but with slightly more side effects. Both drugs have good tolerability.