DOI: 10.36347/sajp

Pages: 340-353

The aim of the present investigation was to develop fast dissolving tablets of Simvastatin, an lipid-lowering drug used for the reduction of VLDL. Due to its low solubility and its short biological half-life of 3 hours, fast dissolving tablets of Simvastatin were prepared using superdisintegrants in order to improve the dissolution rate, thereby the absorption. The influence of concentration of the Ac-Di-Sol was studied by a set of four formulations (F1, F2, F3, F4) with concentrations of Ac-Di-Sol viz, 2%, 3%, 4% & 5%w/w respectively. Also the influence of various superdisintegrants was studied by a set of three formulations (F4, F5 and F6) with three superdisintegrants viz, Ac-Di-Sol (5%), Croscarmellose sodium(5%), Crospovidone (5%) respectively. The formulation prepared with 5%w/w of Ac-DiSol was offered relatively rapid release of Simvastatin n when compared with other concentrations of Ac-Di-Sol. The formulation prepared with Crospovidone was offered relatively rapid release of Simvastatin when compared with other superdisintegrants. Various formulations were prepared incorporating a combination of superdisintegrants (Physical Mixtures and Co-processed Mixtures), Ac-Di-Sol and Crospovidone by direct compression method. Formulation containing Co-processed mixtures had less disintegration time as compared to the Physical mixtures. So, we can conclude that nature , concentration of the superdisintegrant and type of combination of superdisintegrants (Physical mixing vs Co-processing) showed influence on the rate of dissolution. The dissolution rate was found to follow first order kinetics