DOI: 10.36347/sasjm

Pages: 251-257

Oral lichen planus (OLP) is a chronic inflammatory disease with unknown etiology, and WHO has classified it as a premalignant lesions that could be transformed to oral squamous cell carcinoma (OSCC). Since uncontrolled cellular proliferation is considered the base of malignancy, the aim of this study is the comparison Cyclin D1 immunohistochemical expression in OLP and OSCC. Cyclin D1 immunohistochemical expression was evaluated in 21 samples of hyperplasia without dysplasia, (group :A), OLP (group: B) and OSCC (group: C).Label index of the Cyclin D1 expression was 13.69±6.006, 28.38±3.35 and 66.94±14.49, in A, B, and C groups respectively. Significant difference was found statistically between 3 groups (p<0.001) and between A and B (p<0.009), B and C (p<0.001), A and C (p<0.001).we have seen a statistically significant difference between groups and each 2 groups in semi-quantitative analysis. (p<0.001). The findings of this study with Cyclin D1 showed that cellular proliferation in the lesions of OLP samples is significantly lower than OSCC samples. This will be a warning to clinicians so that patients with OLP, especially those with increased cell proliferation are always followed by regular periodic examinations and detailed and continuous follow-up to detect the slightest changes in lesions in the early stages and provide appropriate treatment.