DOI: 10.36347/sajp

Pages: 354-359

The objective of the present work is to synthesis of N-[2-(4-substituted phenyl)-4-oxo-1,3-thiazoldine-3-yl]-2- (naphthalene-2-yloxy) acetamide and evaluate for anxiolytic activity. Based on this a new series of compounds have been planned to synthesize by reacting β-napthol, ethyl chloroacetate, hydrazinemonohydrate, ethyl alcohol and various aromatic aldehydes. The Anxiolytic activity of the test drugs were evaluated using the experimental Elevated Plus Maze (EPM) and Light-Dark Model (LDM) in mice. The result exhibit the anxiolytic activity among the three synthesized compounds at varying degree. Some compounds also exhibited skeletal muscle relaxant activity