DOI: 10.36347/sjams.2019.v07i03.068

Pages: 1214-1217

Background: Pancytopenia means a condition in which blood elements (red blood cells, white blood cells, platelets) are decreased than normal. It is striking feature of many lives threatening illness, ranging from simple drug induced bone marrow hypoplasia, megaloblastic anemia to fatal bone marrow aplasias & leukemias. Identification of the correct cause will help in implementing appropriate therapy. Common questions that arise among the healthcare professional are: What are the most common causes of pancytopenia? And what is the best diagnostic approach to the pancytopenia patient? Methods: This prospective study was carried out from September 2012 to August 2014 at Pathology department, P.D.U medical college, Rajkot. The cases were selected on the bases of inclusion criteria after taking written & informed consent. Permission from ethical committee for this study was obtained before starting the study. Result: Megaloblastic anemia was the commonest cause of pancytopenia followed by aplastic anemia, granulomatous lesion, SLE, dengue, malaria, MDS, Plasma cell dyscrasia. Conclusion: Amongst the patients presenting with pancytopenia, 77% patients had megaloblastic anemia, 5% patients had aplastic anemia, 5% patients had leukemia, 4% patients had hypersplenism, 2% patients had granulomatous disease, 2% patients had SLE, 2% patients had malaria, 1% patients had dengue, 1% patients had MDS, 1% patients had plasma cell dyscrasia. In present study, most common age group affected was 21 to 30 years followed by 11 to 20 years. In present study, 65% of affected patients were males, and 35% patients were female so, male to female ratio is 1.85:1.