DOI: 10.36347/sajp

Pages: 365-372

The purpose of present work was to develop Metoprolol tartrate microspheres for floating pulsatile release intended for chronopharmacotherapy. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. The floating pulsatile microspheres were prepared by emulsification solvent evaporation technique. The best batch exhibited excellent floating time as well as release at desired time. The particle size was controlled by changing polymer concentration and emulsifier concentration. Polymers used for the preparation were Eudragit L 100 and Eudragit S 100. The floating microspheres provided two phase release pattern with initial lag time during floating in acidic medium followed by rapid release in phosphate buffer. This approach suggested the use of floating pulsatile microsphere as promising drug delivery for site and time specific release of Metoprolol tartrate for chronotheraphy of hypertension