DOI: 10.36347/sjams.2019.v07i03.088

Pages: 1300-1304

Introduction: Diabetes mellitus is associated with a high risk of bacterial infections. This is related to the harmful effect of hyperglycaemia on cellular immunity. These infections are associated with a heavy morbidity and mortality in this population. The main purpose of this study was to determine the etiological agents of these infections and to establish the current profile of antibiotic resistance of bacteria isolated. Materials and methods: This was a prospective study carried out in the Department of Bacteriology-Virology at the University Hospital of Marrakech for a period of 18 months (July 2016-December 2018), including all diabetic patients infected hospitalized Or externally, and who have benefited from a sample for cytobacteriological study. All the samples received were directly examined, and then a culture and antimicrobial susceptibility tests were performed. Results: A total of 692 specimens were collected during the study period, containing mainly Bacteriological examination of urine BEU (n = 416) and diabetic foot (n = 263). Mean patient age was 45 years, the Sex ratio F / H was 2.5. The type 1 diabetes accounted for 60% of the infected patients. Microbiologically, Gram Negative bacteria dominated the profile of these infections in 73% of the cases. Enterobacteriaceae were responsible for 58 % of infections, Escherichia coli was the dominant pathogen (25.5%) followed by Klebsiella pneumoniae (18.5%). High resistance rates to antimicrobial agents were recorded especially to amoxicillin (85.5%), 53% for amoxicillin/clavulanic acid and 50% for cotrimoxazole. third generation cephalosporins and aminoglycosides preserved an effective activity on these enterobacteriaceae. Conclusion: The frequency and severity of infections in patients with diabetes mellitus, besides to the increasing resistance of germs underline the importance of prevention based on the education of the patients with diabetes mellitus and the early and adapted management of this pat