DOI: 10.36347/sjams.2019.v07i03.092

Pages: 1315-1321

Ovarian carcinoma (OC) is one of commonest cancers ranks 7th in both incidence and mortality among women worldwide. The study included fifty three samples of ovarian tumors patients, twenty eight of them were malignancy and twenty five were benign. Those patients' samples then compared with twenty three free-cancer tissues samples as control group. This study was carried out in Laboratories of the College of Science/ Department of Biology, Wasit University; during period between 1 November 2017 to 1 November 2018. The study of CK7 and HOXB4 genes expression was evaluated by immunohistochemistry technique. The results showed significant increase of CK7 and HOXB4 expression in ovarian cancer patients when compared with control group and benign patients (p<0.05). Moreover, the results showed no significant between benign patients and control group in the expression and intensity of CK7 and HOXB4 (p>0.05).In conclusion, the present study confirms that overexpression of CK7 and HOXB4 play necessary roles in carcinogenesis and development of ovarian malignancy.