DOI: 10.36347/sjams.2019.v07i01.003

Pages: 13-17

Background: Hepatitis B infection is a constant threat despite availability of effective vaccine. Patients with Chronic Kidney Disease (CKD) have higher risk of acquiring Hepatitis B infection and further progressing to become chronic carrier. Present research aims to study seroconversion rates of Hepatitis B vaccination in pre-dialysis and dialysis patients. Also it aims to correlate seroconversion with the nutritional status of the patients. Methods: This is a hospital based observational study conducted in tertiary healthcare facility. Total 110 participants were enrolled for the study after obtaining written informed consent. Demographic information was captured using standardized questionnaire. Nutritional assessment was done by calculating BMI, Lean body mass and Mid Arm Circumference (MAC). Anti HBsAb estimation has been done before beginning of schedule and 1 month after last dose. Data entry and analysis done using statistical software SPSS version 20.0. Results: Out of total 110 patients 69 (62.7%) were males and 41 (37.3%) were females. The mean age of the patients was 46.6±11.85 years. Seroconversion rates were significantly higher (p value=0.014) in the pre-dialysis group (89.4%) than the dialysis group (69.8%). There were significant higher seroconversion rates (p value <0.05) among subjects who have better BMI, Lean Body Mass and MAC. Conclusion: Vaccination with HBV in early CKD gives a chance for higher seroconversion. Patients can be screened for CKD and can be immunized at the earliest for better antibody titre.