DOI: 10.36347/sjams.2019.v07i01.017

Pages: 96-101

Diabetic Nephropathy also known as Kimmelsteil-wilson syndrome is the most common cause of End Stage Renal Disease (ESRD) and is the major cause of Diabetes related morbidity and mortality. Earlier, microalbuminuria is highly regarded to be the best indicator to assess the progression of diabetes to End Stage Renal Disease and cardiovascular complications. Now there are sensitive and specific markers available to help us in diagnosing renal damage and treating diabetic nephropathy even at an earlier stage to prevent further development into ESRD. This study is to evaluate the usefulness of urine Neutrophil Gelatinase Associated Lipocalin (NGAL) as a marker for the early detection of Diabetic Nephropathy. Study group comprised of 120 subjects; of whom Cases were 90 and classified into three groups Normoalbuminuric, Microalbuminuric and Macroalbuminuric based on Urine Albumin Creatinine Ratio. 30 healthy gender and age matched subjects were taken as control group. Urine NGAL was estimated by Enzyme Linked Immunosorbent Assay. Other parameters like Plasma Blood Glucose, Urine abumin and Urine Creatinine were estimated. Mean Fasting Blood Glucose, Urinary Albumin Creatinine Ratio and Urine Neutrophil Gelatinase Associated Lipocalin showed significant difference between groups (p<0.001). Urine Neutrophil Gelatinase Associated Lipocalin had a positive correlation with Urine Albumin Creatinine Ratio.Urine Neutrophil Gelatinase Associated Lipocalin levels were higher in patients with Normoalbuminuria in whom the Urine Albumin Creatinine Ratio was normal.