DOI: 10.36347/sjams.2019.v07i01.061

Pages: 345-347

Urinary tract infections are the most common infections encountered in hospitals. With the increase in antibiotic resistant isolates, old antibiotics like Fosfomycin and Nitrofurantoin have gained importance. The present study was undertaken to evaluate the susceptibility patterns of Fosfomycin and Nitrofurantoin among the Gram negative uropathogens and also among the Extended Spectrum Beta Lactamase producers. A total of 201 mid-stream urine samples were processed by conventional methods. Identification of pathogens was done by standard biochemical tests and antimicrobial susceptibility testing was done by Kirby-Bauer’s disc diffusion method and ESBL production was confirmed by combination disc test as per CLSI guidelines. Out of 201 urine samples, 73 samples were culture positive for Gram negative bacilli. Most common isolate was Escherichia coli (46.6%), followed by Klebsiella species (24.7%), Citrobacter spp (12.3%), Pseudomonas aeruginosa (8.2%), Proteus species (4.1%), Acinetobacter spp(4.1%). ESBL producers were 46.6%. In the present study, overall sensitivity to Fosfomycin was 100% whereas Nitrofurantoin was sensitive in 83.5% isolates. In our study, most of the uropathogens including the ESBL producers showed high susceptibilities to Fosfomycin and Nitrofurantoin. Therefore their role in empirical treatment of uncomplicated UTI’s should be considered.