DOI: 10.36347/sjams.2019.v07i01.072

Pages: 394-399

Bone metastasis is frequently the first sign of malignancy when the primary has not been discovered. Thus, histopathological examination of the affected bone helps in its characterization and localization of primary site. A study of 110 patients with metastatic bone tumors was done. Histopathological diagnosis of biopsy tissues was obtained on formalin fixed, paraffin embedded tissue and stained with hematoxylin and eosin. Decalcification was done with nitric acid. The mean age of patients was 47.5 years with 63 males and 47 females. Bone pain and haematological abnormalities (thrombocytopenia, bicytopenia and pancytopenia) were the most common presenting symptoms. 84 patients (76.4%) were found to have multiple metastatic lesions in their skeleton. The most common location of metastasis in our study is spine, followed by pelvis. Sixty eight patients had their metastatic disease diagnosed in Core biopsy specimens while Trephine biopsy was used in 42 patients. Metastatic adenocarcinoma was the most common tumour diagnosed, making up 69.1% (76 patients) of the total. The primary site varied between the genders. Lung was the most common primary in males followed by Prostate, while in females, it was Breast followed by Lung.