DOI: 10.36347/sjams.2019.v07i02.015

Pages: 497-501

Metabolic syndrome is a constellation of metabolic abnormalities that results in increased risk of Cardiovascular disease and Diabetes mellitus. Triglyceride/High-density lipoprotein cholesterol (TG/HDL-C) ratio is suggested as a compliment to Low density lipoprotein choles¬terol (LDL-C) for predicting the risk of development of Cardiovascular diseases and Diabetes. The aims and objectives are to estimate and compare TG/HDL-C ratio between controls and Metabolic syndrome patients and to assess the correlation between TG/HDL-C ratio and number of components of Metabolic syndrome. A case control study was conducted at Tirunelveli Medical College Hospital during July to October 2018. The subjects attending OPD were allocated into groups with and without Metabolic syndrome, matched by age and gender. Adults aged 20-70 years were en¬rolled. Subjects with a history of Angina pectoris, Myo-cardial infarction, Stroke and Cancer were excluded. Fasting venous blood samples were used for estimation of Fasting Plasma Glucose (FPG), Total Cholesterol, Triglycerides, HDL-C, LDL-C. Of 120 subjects enrolled, 67 were cases and 53 were controls. Statistically significant positive correlation was found with TG/HDL-C ratio and weight, FPG in cases. In study subjects, TG/HDL-C ratio increased significantly with the increase in the number of components of Metabolic syndrome. In the Odds Ratios (ORs) of Metabolic syndrome according to TG/HDL-C ratio quartiles, the risk of developing Metabolic syndrome in males is 25 times greater in quartile 3 than in quartile 1 and 34 times greater in quartile 4 when compared with quartile 1. For females the risk of developing Metabolic syndrome is 14 times greater in quartile 4 than in quartile 1. On conclusion the TG/HDL-C ratio is significantly associated with Metabolic syndrome. Assessment of TG/HDL-C ratio will be more valid and useful for early detection and treatment of Cardiovascular disease and Diabetes mellitus.