DOI: 10.36347/sjams.2019.v07i02.041

Pages: 636-638

Preeclampsia is one among the leading cause for maternal and fetal morbidity and mortaility. Its pathophysiology is poorly understood in spite of intensive research. This case-control study was aimed to determine the level of inflammatory biomarker hsCRP and uric acid and the association of these biomarkers and preeclampsia. Serum uric acid and hsCRP were measured in 30 women in the third trimester of pregnancy with mild preeclampsia, 20 women in the third trimester of pregnancy with severe preeclampsia and compared statistically with 50 healthy age matched normotensive women in the third trimester of pregnancy. The statistical analysis was done by Student t-test and Anova in SPSS version 17.0. Both serum hsCRP and uric acid were found to have significant positive correlation with the severity of preeclampsia. From this study it may be concluded that hsCRP and uric acid levels were increased and contribute to the pathogenesis of preeclampsia. They may be used as additional biomarkers to predict the severity of preeclampsia.