DOI: 10.36347/sjams.2019.v07i02.042

Pages: 639-643

Angiotensin converting Enzyme (ACE) plays an important role in maintaining blood pressure homeostasis and vascular integrity. The Insertion/Deletion polymorphism (I/D) in exon 7 of Angiotensin converting Enzyme (ACE) gene have been found to be associated with essential hypertension in different human populations. The aim was to study the insertion/ deletion (I/D) polymorphism of ACE gene in patients with essential hypertension and also to assess the genotype distribution and to determine allelic frequency of ACE gene. The target DNA sequence of ACE gene was amplified by Polymerase Chain Reaction (PCR) technique to detect the presence of ACE gene Insertion / Deletion (I/D) polymorphism in 41 patients with essential hypertension. The study results showed that the frequency of I/I, D/D and I/D genotypes was found to be 44%, 27%, and 29% respectively. The frequency of insertion (I) and deletion alleles was found to be 58.54% and 41.46%. The study data indicates, the wild I/I genotype is predominant and the frequency of I allele is increasingly distributed in the studied hypertensive subjects of our study population.