DOI: 10.36347/sjams.2019.v07i02.058

Pages: 715-718

The present study was conducted in the Department of Biochemistry in collaboration with Department of Medicine at Shri Aurobindo Institute of Medical Sciences and P.G. Institute, Indore, Madhya Pradesh, India. The study included 70 cases of hypothyroidism and 40 cases of normal healthy individuals (euthyroids) as controls. In the present study results showed the patients with hypothyroidism found lower mean value of T3 (mean SD=0.43±0.16 vs. 1.28±0.21) and T4 (mean SD=2.64±0.97 vs. 8.87±1.42) while increased mean of TSH (61.86±24.94 vs 2.71±0.84) on comparison with control group, which were all statistically highly significant (P<0.001). The fasting lipid profile (mg/dl) mean values were found higher including TC, TG, LDL-C and VLDL-C (252.41±18.52 vs 151.94±25.29, 220.76±18.36 vs 111.85±22.97, 180.02±14.81 vs 85.34±22.10 and 44.15±3.67 vs 30.38±5.06) while HDL-C (28.49±4.15 vs. 44.64±8.72) level was lower in patients with hypothyroidism than control group respectively, all were highly (p<0.001) statistically significant. The hypothyroid patients showed increased mean value of hs-CRP (4.09 ± 1.26 vs 0.97 ± 0.33) than compare to control group, which was highly (p<0.001) significant. It can be concluded that the hypothyroidism affects higher levels of serum lipids and CRP levels that can cause the inflammation in body or arteries directly or indirectly. The both the factors higher lipid levels and inflammation in hypothyroidism patients can exert an additive effect on the risk of atherosclerosis and cardiovascular disease in hypothyroidism patients. Hence, the patients should be screened for lipid profile and hs-CRP levels with thyroid disorders which can be help in diagnosis and prognosis of the cardiovascular diseases.