DOI: 10.36347/sjams.2019.v07i02.067

Pages: 749-751

Type 2 Diabetes Mellitus (DM) is emerging as a serious metabolic disease throughout the world. Type 2 DM is associated with characteristic dyslipidemia like elevated Total Cholesterol, Triglycerides, LDL levels and low HDL levels. Serum Butyrylcholinesterase (Pseudocholinesterase) is a non-specific esterase that hydrolyses choline esters. Pseudocholinesterase activity has been shown to be elevated in Diabetes Mellitus. It may be due to an increase in the hepatic synthesis of the enzyme in response to elevated insulin and free fatty acid levels in Diabetes Mellitus. To evaluate Serum Cholinesterase activity in Type 2 DM patients and to find out any correlation between Serum Cholinesterase activity, Fasting Plasma Glucose (FPG), Body Mass Index (BMI) and Serum Lipid profile in these patients. A case-control study was conducted in Tirunelveli Medical College Hospital, Tirunelveli. 50 Type 2 Diabetic Mellitus patients and 50 age and sex matched apparently healthy subjects were taken. Serum Cholinesterase activity, FPG and Serum Lipid profile was measured in all the study subjects. The correlation between Serum Cholinesterase activity and other parameters was done by Pearson correlation method. Mean Serum Cholinesterase activity in the Diabetic cases (9470 ± 962 IU/L) were higher than that of the control group (6493 ± 831 IU /L) with statistical significance (p < 0.001). A significant correlation was also observed in the Diabetic cases between the Serum Cholinesterase activity and FPG, BMI, Total Cholesterol, TGL, HDL with p <0.001 and LDL with p <0.05. From our study it is shown that Serum Cholinesterase activity is elevated in Type 2 Diabetes Mellitus patients and a significant correlation has been found between the Serum Cholinesterase activity and the lipid alterations found in DM. Thus, Diabetes Mellitus is associated with elevated Serum Cholinesterase activity probably due to abnormal lipid metabolism.