DOI: 10.36347/sajb.2015.v03i05.001

Pages: 413-420

The leaf and stem bark of Canarium schweinfurthii were investigated. The result reveals the presence alkaloids, tannins, phenolic compounds, flavonoids, cardiac glycoside, saponins and steroids. The leaf and stem bark crude extracts showed Zone of inhibition ranging between 20 to 30 mm on Methicillin-resistant Staphylococcus aureus, other zone of inhibition in the range, 25 to 26 mm (Hexane), 25 to 30 mm (chloroform), 26 to 32 mm (ethylacetate) and 27 to 42 mm (methanol) were also observed. Against the test organisms; MRSA, Vancomycin Rest Enterococci, Staphylococcus aureus, Streptococcus pyogenes, Bacillcus subtilis, Escherichia coli, Salmonella typhi, Klebsiella pneumonia, Pseudomonas aeruginosa, Proteus mirabilis, Shigella dysenteria, Candida albicans, Candida krusei, Candida tropicalis and Candida Stellatoidea. The ethyl acetate fraction (leaves) recorded a lowest Minimum Inhibitory Concentration of 6.25 mg/mL against MRSA and most of the bacteria except Salmonella typhi. The stem bark, hexane, ethylacetate and chloroform fractions recorded a MIC of 6.25 mg/mL against Staphylococcus aureus, Bacillcus subtilis, Salmonella typhiand Klebsiella pneumonia. Both recorded a MIC of 12.5 mg/mL against Candida. The minimum bactericidal/fungicidal concentration (MBC/MFC) determination showed that a concentration of 12.5-50 mg/mL of the hexane, chlororform, ethyl acetate and methanol fraction could completely kill the entire test organism except Streptococcus pyogenes and Proteus mirabilis.