DOI: 10.36347/sajb.2015.v03i05.004

Pages: 434-442

Exposure to aluminum is always associated with oxidative stress, while, oxidant imbalance is a common observation for degenerative neuropathologies. Recently, oxidative stress and cognitive impairment were associated together for the neurodegenerative processes and age-related behavioral pathologies were linked with neuroglial oxidant homeostasis. This study is aimed to explore the implication of external oxidant interventions in the aluminum induced neurobehavioral toxicity to evaluate the role of oxidant balance in functional neurodegenerative changes. Male NIN-Wistar rats were exposed to aluminum (Al+) or vehicle (Al0) for 4 weeks. During the period of aluminum exposure, the animals were also exposed to ethanol (0.2-0.6 g/Kg bw) and -tocopherol (5 IU/day). After the completion of treatment protocol, their behaviors were evaluated with the help of elevated plus maze (EPM) and passive avoidance (PA) test. Time spent at different places, acquisition time (transfer latency), retention of memory for 24hrs and 48hrs were evaluated for the behavioral tests. All data were processed through two-way ANOVA with replication to find out the impact of aluminum treatment and oxidant imbalance.