DOI: 10.36347/sajb.2015.v03i09.011

Pages: 796-803

Helicobacter pylorus (H. pylori) a spiral, urease producing organism and is a important pathogenic factor in peptic ulcer disease (PUD). Extensive molecular studies suggest that the bacteria cause gastritis by stimulating production of proinflammatory cytokines and by directly injuring epithelial cells. Study was done to know the gastric mucosal histological features in H. pylori positive gastric biopsies and categorization of lesions, and also to know the association of H. pylori with various parameters such as age, sex, site, colonization of organisms, spicy diet, smoking and alcohol intake, Intestinal Metaplasia. A total of 261 gastric biopsies were received. Out of which 131 biopsies were positive for H. pylori were included in this study by using various clinical parameters. In our study, dominant age group was 30 – 60 yrs with 83 (63.4%) cases and H. pylori was associated with chronic gastritis -115 (87 %), Male to female sex ratio was 1.04: 1. Antrum was the predominant biopsied site which constituted 117 cases out of a total of 131 cases i.e. 87.3%.14 biopsies were from gastric body i.e. 10.4% and 3 biopsies were from fundus region. Mild colonization was seen in 73 (54.5%) biopsies, moderate in 29 (21.6%) biopsies and severe in 32 (23.8%) biopsies, total being 134, as 3 patients had biopsies from 2 different sites. There were 2 (1.5%) cases associated with Gastric ulceration in our study. One case each was associated with granuloma formation and malignancy, in the background of chronic active gastritis.