DOI: 10.36347/sajb.2015.v03i10.004

Pages: 842-844

A series of 2-Arylidene-4-(4-Phenoxy-Phenyl) But-3-en-4-olides were screened against Pheretima posthuma earthworm for anthelmintic activity. The in vitro effects of compounds were evaluated at a concentration of 2mg/mL and time taken by the compounds to paralyze and subsequently kill the worms was recorded. Butyrolactone derivatives exhibited moderate to good anthelmintic activity but among all tested compounds IV was found to be the most potent against Pheretima posthuma. The anthelmintic activity of compound IV was observed to be comparable with positive control albendazole.