DOI: 10.36347/sjams.2016.v04i07.003

Pages: 2322-2327

Erythrocytes are involved in a developing thrombus or clot formation. Increased endothelial adherence of red blood cells with endothelium by increase adhesive proteins has been observed. The causes that effect EAAT include proteins of acute-phase response and changes in the phospholipid composition of erythrocyte membrane especially in a case of hyperlipidemia. The aim is to study erythrocyte aggregation and adhesiveness by a simple slide test in subjects with acute ST-elevated myocardial infarction (STEMI) in predicting the outcome within 1week. Fifty patients of acute STEMI who came to the ICCU of Government Royapettah Hospital were included in the study. Subjects with onset of chest pain within 6hrs, with retrosternal chest pain persisting for more than 30 min and with ST segment elevation more than 1mm in limb leads and more than 2mm in chest leads in at least two contiguous ECG leads were included in the study. Citrated blood was subjected to simple slide test and Stained smears were examined under 400Χ and graded into four grades. ‘P’ value between the Grades of RBC aggregation and the prognosis of the patients with STEMI was < 0.05. EAAT is a simple bedside slide test for erythrocyte aggregation, which indirectly finds out the presence and proportion of inflammation. This test also has the potential to assess the prognosis of STEMI patients. It can also be used as a screening test for patients with STEMI to find out high-risk individuals so that necessary interventions (like PCI) could be adopted.