DOI: 10.36347/sajp

Pages: 191-196

In the present study, an attempt was made to design and evaluate a press coated tablet of Losartan Potassium, in Order to overcome bioavailability problems, to reduce dose dependent side effects and frequency of administration. The tablets, each consisting of a core and a coat, were prepared using compression coating technique. The coat layer consists of HPMC K100M and Ethyl cellulose in different ratio. The tablets were evaluated for different parameters like weight variation, friability, in-vitro release, content uniformity, Hardness. Observations of all the formulations for physical characterization had shown that, all of them comply with the official compendia’s. Results of in- vitro drug release profile from all formulations (F1-F4) showed slow and sustained release of Losartan potassium over a period of 12 hours. Hydrophilic polymer like, HPMC K100M (60%) and Ethyl cellulose (10%) was found to be optimum. HPMC K100M was useful in the formation of matrix and Ethyl cellulose was used as its swellable and rupturable behavior. DSC and IR studies show no evidence on interaction between drug, polymers and other excipients. The best fit model for the optimized batch was peppas having r value 0.9938, n value 0.6998 and K value is 19.5516.