DOI: 10.36347/sajp

Pages: 208-212

The present study deals with in vitro antibacterial and antifungal screening of some novel pyrano[2,3-c] pyrazole derivatives. A series of novel 6-amino-4-(aryl/heteroaryl) phenyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5- carboxamide derivatives were synthesized by condensation of a mixture of ethyl acetoacetate, aryl/heteroaryl aldehyde, hydrazine hydrate, 2-cyanoacetamide and triethylamine in methanol as a solvent. The structures of all the synthesized compounds are assigned on the basis of IR, 1H NMR and Mass spectral data. Most of the compounds showed mild to moderately active against the S. aureus the strain of Gram positive and E. coli the strain of Gram negative. The compounds 1d, 1f and 1g exhibited remarkable antifungal activity against A. niger.