DOI: 10.36347/sjams.2016.v04i07.038

Pages: 2488-2491

Aim of the study was to evaluate the hepatoprotective activity of ethanolic seed extract of Lawsonia inermis against paracetamol induced liver damage in rats. Wistar albino rats of either sex were divided in to 5 groups of 6 each. The rats were intoxicated with paracetamol (750mg/kg) at every 72 hrs for 21 days. Silymarin (50mg/kg) and Lawsonia inermis (200 & 400 mg/kg) were orally administered once daily for 21 day by suspending in 0.1% Carboxy Methyl Cellulose solution. On 22nd day blood was collected through retro orbital puncture and the serum was subjected to liver function tests like, SGOT, SGPT, SALP, biliubin and total protein. Lawsonia inermis (400mg/kg) showed significant significant increase in SGPT (P<0.05), SGOT, SALP, total protein (P<0.05) and significantly decrease the total bilirubin (P<0.01) level. From the above result it was concluded, that Lawsonia inermis seed extract exhibited hepatoprotective activity against paracetamol induced hepatic damage in rats.