DOI: 10.36347/sajp

Pages: 228-239

In present study a new series of 5-substituted - 1, 3, 4-thiadiazolidine Schiff bases have been synthesized. The synthesis involves reaction between various aliphatic/arylaldehydes/ ketones with 5-substituted -2-amino -1, 3, 4- thiadiazolidines. The structures of synthesised compounds were established on the basis of IR, 1HNMR spectral data. Insilco analysis was carried, aiming to present potential selective activities as ion channel modulator and enzyme inhibitors. These activities were suggested by the score values using molinspiration cheminformatics programme. In vitro antibacterial and antifungal activity were also evaluated and compared with standard drugs.