DOI: 10.36347/sajp

Pages: 271-279

Bi-layer tablet is a new era for successful development of controlled release formulation along with various features to provide successful drug delivery. Bilayer layer tablets have been consist of two layers which is slow release and immediate release layer. As well as improved beneficial technology to overcome the shortcoming of the single layer tablets. The preparations of bilayer tablet were needs due to separate incompatible active pharmaceutical ingredient (APIs) for each other. Bilayer tablets material involves both the compressibility and consolidation. The bilayer tablets preparing by using different techniques such as OROS® push pulls Technology, L-OROSTM Technology, EN SO TROL Technology, DUREDAS™ Technology and DUROS Technology. Various types of bilayer tablet press currently available in the market, various approaches used in bilayer tablet system, characterization as well as evaluation of the bilayer tablet system. Now a day’s bilayer tablets are prepared such as ―Atorvastatin, Atenolol‖, Nifedipine, ―Aspirin, Isosorbide 5-mono-nitrate‖, ―Pioglitazone HCl, Gliclazide‖, Losartan potassium, and ―Trimetazidine hydrochloride, clopidogrel bisulphate‖