DOI: 10.36347/sjams.2016.v04i08.038

Pages: 2918-2923

Antibiotics are medications that are used to prevent and treat bacterial infections. Irrational use of antibiotics is a common problem which leads to antibiotic resistance and adverse reactions. In general surgeries there are a number of antibiotics that are being used for number of conditions however judicious selection and use of antibiotics are of utmost importance. This study tries to find the antibiotics used in General Surgery in different patients and find out if there are any adverse reactions reported by their use. The study was conducted in Shadan Medical College Hospital and Research Center the patients were randomly selected from the Department of General Surgery and 100 cases were selected and studied. All the data was recorded including the drug efficiency and compliance and ADR based on Naranjo Scale. Most common condition causing the use of antibiotics was Cholecystitis 29% followed by Inguinal Hernia 25% and Appendicitis 20%. Most common Route of administration was IV 82%, most common IV antibiotics used were Beta-Lactum group 66.65% most common of antibiotic used was Cefipime + Sulbactam 19.5%. Around 25% of subjects reported with Adverse Drug Reactions, the commonest ADR was Nausea 8% Vomiting 5% Diarrhoea 4%. Antibiotics are commonly prescribed before, during and after surgical procedures. The best results were obtained from Beta-lactam class of antibiotics were as Fluroquinolones and Antifungal agents were found to be effective only 50% of patients. Adverse Drug Reactions were minor and well managed. However use of culture and sensitivity and more strict prescription pattern should be followed in order to overcome the bacterial antibiotic resistance which is a potential threat for use of antibiotics.