DOI: 10.36347/sjams.2016.v04i08.055

Pages: 3020-3027

Lung cancer and Pulmonary Tuberculosis are two major public health problems associated with significant morbidity and mortality in India. Wrong diagnosis of lung cancer cases as pulmonary tuberculosis delays the onset of anti-cancer chemotherapy and initiation of DOTS thus increases complication in malignancy patients. In this context easy, cost effective diagnostic tool at primary level must be the priority and need of hour. This study was done to evaluate any significance of ADA, CYFRA 21-1in serum and pleural effusion secondary to tuberculosis and lung cancer. Case control study was carried out on 100 cases of tuberculous effusion, 50 cases of malignant effusion and 100 age and gender matched apparently healthy controls. Correlation between ADA and CYFRA 21-1 was evaluated to find any significance between three groups. Blood and pleural fluid samples were collected and analyzed by using Erba Mannheim Chem 5 plus V2 semi autoanalyzer and LISA SCANII Elisa reader. Statistical analysis was done by using ANOVA and student’s‘t’ test. P value <0.05 was considered significant. ADA levels in serum and pleural fluid was significantly higher in pulmonary TB group than lung cancer group(‘p’ <0.001) and both are higher than control group(‘p’<0.001).CYFRA 21-1 in serum and pleural fluid was significantly higher in lung cancer group than TB group(‘p’ < 0.001) but both were higher than control group(‘p’<0.001). The results suggests early quantization of these parameters can differentiate pulmonary tuberculosis from lung cancer and thus can decrease the mortality rate of lung cancer cases though more extensive study with increased sample size may provide more insights.