DOI: 10.36347/sjams.2016.v04i08.067

Pages: 3079-3082

There is evidence of opposite relationship between creatine kinase and thyroid dysfunction disorders. This study aimed to evaluate serum CK level in hypothyroidism and hyperthyroidism patients and find its correlations with thyroid function tests. In this cross-sectional study 200 hundred subjects diagnosed with thyroid dysfunctions referred to advanced diagnostic center-Khartoum- Sudan were involved. A 100 had hypothyroidism aged 35±10) years while other 100 ones had hyperthyroidism aged (42+11) years. Laboratory analysis of thyroid function tests (TFT) via i-chroma, device, an immuno chromo genic process, and serum CK enzyme activity measurement via spectrophotometer, Bio system device were performed for all participants. Statistical analysis for the data obtained was conducted via spss program version 16. The CK activity level was significantly increased in hypothyroid patients compared to hyperthyroidism patients (183.2±34.2vs 47.2±12.6, p.value 0.001). In hypothyroidism patients, the serum activity level positively correlated with TSH level. In hyperthyroidism patients there was negative correlation between CK activity and duration of the disease. CK is considered a marker for variety of systems abnormalities as muscular damage and others, it could be used as monitor for thyroid dysfunction treatment state.