DOI: 10.36347/sjams.2016.v04i08.072

Pages: 3107-3112

Diabetes mellitus (DM) describes a metabolic disorder of multiple etiology, which is characterized by chronic hyperglycemia, with disturbances of carbohydrate, fat and protein metabolism, which result from defects in insulin secretion, insulin action. The objective of this study was to assess some of the biochemical parameters related to types 2 diabetic patients. It was a descriptive, case control hospital based study. 250 Sudanese patients with Type 2 diabetes mellitus were involved as test group and 150 apparently healthy subjects (non-diabetics) as control group. Age and sex of both groups were matched. The Plasma Malondialdehyde(MDA), Uric Acid and other blood parameters were measured using spectrophotometric methods. The (mean ±SD) of MDA, uric acid and glucose of patients were(63.8±40.7, 4.3±1.7, 196.6±75) respectively, compared to healthy subjects(49.8±30.0, 3.7±1.0, 93.5±10.5)respectively. There was significant increase of malondialdehyde and uric acid in patients compared to control groups (P value ≤ 0.05).From this study concluded that, increased of malondialdehyde and uric acid in patients compared to control groups.