DOI: 10.36347/sjams.2016.v04i08.080

Pages: 3142-3145

Hypothyroidism, also called underactive thyroid or low thyroid, is a common disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormone. It can cause a number of symptoms, such as poor ability to tolerate cold, a feeling of tiredness, constipation, depression, and weight gain. The association between thyroid autoimmunity and lipoprotein (a) levels is controversial. Hyperthyroidism may be the underlying cause for acquired hypocholesterolemia or unexpected improvement of the lipid profile of a previously hyperlipidemic patient. Using a cross sectional analytical study design, a total of 50 subjects attending Out Patient Department, of, vinayaka mission Medical College, karikal 25 newly diagnosed hypothyroid patients (Group I) and 25 healthy adults (Group II) were enrolled in this study. Serum thyroid stimulating hormone and serum free thyroxine were assayed by radioimmunoassay. Serum fasting lipid profile, serum creatinine and serum uric acid were estimated by enzymatic colorimetric method. The mean Serum total-cholesterol, LDL- cholesterol and triglycerides in Group I were significantly higher than that in Group II. Serum HDL cholesterol in Group I was significantly lower than that in Group II The mean serum creatinine, urea and uric acid was significantly higher in Group I than Group II. Hypothyroidism is associated with dyslipidemia hyperuricemia and impaired renal function. Therefore, patients presenting with these biochemical abnormalities are recommended to be investigated for hypothyroidism and vice versa.