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Scholars Academic Journal of Pharmacy | Volume-3 | Issue-03
A New Method Development and Validation for Quantitative Estimation of Olmesartan Medoxomil in Pharmaceutical Dosage form by UV spectrophotometry
M.Vijayakumari, K. Prasadbabu, K. Lakshmi Prasanna, P.Sowjanya, M.Prathap
Published: March 30, 2014 |
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DOI: 10.36347/sajp
Pages: 317-320
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Abstract
A Simple, Sensitive,Precise,Accurate and Linear Spectroscopic Method has been Developed and Validated for
the Estimation of Olmesartan Medoxomil in Tablet Dosage form. The λmax of Olmesartan Medoxomil was Determined
by using Acetonitrile : Methanol(1:1) as Solvent and Absorption Maxima of Olmesartan was found to be 257nm.The
Linearity was obtained in the Range of 5-15 ug/mL and Coefficient of Correlation was found to be 0.9997.The %RSD
was found to be below 2.0 for Repeatability and Interday Precision indicated that the Method was highly Precise. The
LOD and LOQ were found to be 0.26 & 0.8ug/ml revealed that the method was Sensitive. The percentage recovery value
was found to be 100.12% to 101.87 %, indicating the accuracy of the method and absence of interference of the
excipients present in the formulation. The proposed method was simple, fast, Specific, accurate, precise, Rugged and
reproducible and hence can be applied for routine quality control analysis of Olmesartan Medoxomil pharmaceutical
formulations.