DOI: 10.36347/sjams.2016.v04i09.011

Pages: 3236-3241

The present study has been undertaken to evaluate the changes in serum level of urea, creatinine, and uric acid in normal pregnant women (during 1st and 3rd trimester of pregnancy) and compare it with non-pregnant women. During the study, 76 pregnant women were seen in the 1st trimester but only 48 pregnant women continued the follow up through out to 3rd trimester of pregnancy. 48 non-pregnant healthy women were selected as control group. The estimation of the biochemical parameters were carried out by using Chem 5 plus semi-autoanalyzer. Our study shows that mean ± SD of serum urea, creatinine and uric acid levels significantly decreased during the 1st trimester of pregnany as compared to control group while the non significant decrease level was observed in 3rd trimester of pregnancy as compared to non pregnant healthy women. Comparison between 1st and 3rd trimester of pregnancy and found that the serum urea concentration of 1st and 3rd trimester of pregnancy was not significant while significance difference was found between serum creatinine and uric acid levels. The biochemical parameters serum urea, creatinine and uric acid are affected by pregnancy in the 1st trimester more than the 3rd trimester.