DOI: 10.36347/sajp

Pages: 321-326

The objective of the present study was to develop and evaluate hepatoprotective polyherbal tablet because designing of oral herbal formulation is still a challenge in modern pharmaceutics and the tablet formulation presents many technical problems to the industrial pharmacist. Potential hepatoprotective herbs were used for developing polyherbal tablets. Aqueous extract of whole plant of Momordica dioica, Phyllanthus amarus and Cassia occidentalis were used in different concentrations in the formulations. The granules were prepared by a wet granulation technique using isopropyl alcohol. Preformulation study was done to evaluate pre -compression parameters of powder blends. Tablets were prepared by using hand rotating single punch tablet press and were evaluated for post compression parameters, i.e. uniformity of weight, general appearance, hardness, friability, disintegration and in-vitro dissolution. Tablets were also subjected for the accelerated stability for the period of three months at accelerated temperature conditions. No marked changes were noticed in all the evaluated parameters during three months of accelerated stability study. The laboratory scale preparation of polyherbal tablet may be used as a stable, solid dosage form and the work done in stability testing may help in the progress of shelf-life determination studies.