DOI: 10.36347/sjams.2016.v04i09.065

Pages: 3487-3490

Patients with the overlap syndrome typically experience more pronounced nocturnal oxygen desaturation and have a high prevalence of pulmonary hypertension, which further predisposes to respiratory failure. The aim of this study was done to find out prevalence of OSA with Type 2 Respiratory Failure in COPD patients and additional objective was to find any diurnal variation in BGA among subjects. The present prospective study was carried out in the Department of Pulmonary and Critical Care Medicine, Pt. B. D. Sharma PGIMS Rohtak for a period of 20 months i.e. during July 2012 to February 2014. Patients seeking care and diagnosed with COPD formed the study population. COPD patients stable for at least six weeks were included in this study. Mild COPD patients, IHD patients, any co-morbid state, known case of OSA and patients having COPD with acute exacerbation were excluded. Polysomnography was done using Somnologica studio 3.3.2 Embla N7000 sleep unit system. Blood gas analysis was done in all patients in morning and evening. Prevalence of Overlap Syndrome with Type 2 Respiratory Failure in patients of COPD was found to be 12.5% (5 out of 40 subjects). PCO2 and HCO3 varied significantly among cases and controls when BGA analysis done in the morning and evening. pH also varied significantly among cases and controls in the morning samples. O2 saturation significantly varied on morning – evening time blood gas analysis among cases. Prevalence of Overlap Syndrome with Type 2 Respiratory Failure in patients of COPD was found to be in the higher range in North Indian population.pCO2 and HCO3 varied significantly among cases and controls when BGA analysis done in the morning and evening. O2 saturation significantly varied on morning – evening time blood gas analysis among cases.