DOI: 10.36347/sajp

Pages: 344-349

Sulphonamides are an important class of heterocyclic compounds which possess wide spectrum of biological properties.The present work deals with the synthesis of some novel Sulphonamide derivatives using acetanilide, chlorsulphonic acid and various aromatic amines. All the synthesized compounds were characterized by IR, 1H NMR and13C NMR Spectroscopy. The compounds were evaluated for their antibacterial activity against Staphylococcus aureus 3TCC 3160 and Escherichia coli 3TCC 1652 using Streptomycin as reference standard and anti-inflammatory activity using Diclofenac as reference standard. Some of theanalogues showed significant activity based on the substitutions on the aromatic ring.