DOI: 10.36347/sjams.2016.v04i10.056

Pages: 3837-3841

The aim of the study is to find out the incidence & maternal and fetal outcome in intrahepatic cholestasis of pregnancy. This prospective study was conducted during the period of June, 2015 to May 2016 in Gauhati Medical College and Hospital. Out of 417 cases diagnosed as intrahepatic cholestasis of pregnancy, 100 cases were selected at random for inclusion in our study. Diagnosis of intrahepatic cholestasis was based on clinical and laboratory parameters and disappearance of symptoms after delivery. All the patients were given ursodeoxycholic acid. All cases were followed up to the delivery to find out feto-maternal outcome. Incidence of intrahepatic cholestasis was found to be 2.59%. Most of the cases were diagnosed in third trimester. Pruritus was the chief complaint which was relieved with ursodeoxycholic acid and 100% recovery was observed after delivery. Serum bile acids and Liver enzymes were raised in all cases. Adverse fetal outcomes were mainly associated with raised maternal serum bile acids level. No significant adverse maternal outcome was observed except increased rate of instrumental delivery including LSCS. Intrahepatic cholestasis of pregnancy is found to be associated with adverse perinatal outcome, incidence of which correlates with raised serum bile acids level. Serum bile acids level should be checked in clinically suspected cases for deciding optimal timing of delivery to avoid adverse fetal outcome.