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Scholars Academic Journal of Pharmacy | Volume-3 | Issue-05
In vitro Cytotoxic Activity of Luffa acutangula on Human Neuronal Glioblastoma and Human Lung Adenocarcinoma Cell Lines
Nipun Dashora, L.S. Chauhan, Neeraj Kumar
Published: May 30, 2014 |
71
101
DOI: 10.36347/sajp
Pages: 401-405
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Abstract
In vitro studies were carried out to evaluate the cytotoxic potential of the ethanolic and aqueous extracts
of Luffa acutangula against human neuronal glioblastoma cells (U343) and human lung cancer cells (A549). Screening
of these extracts was done using the brine shrimp lethality bioassay, MTT assay and SRB assay. The results showed the
significant decrease of the viability of the cells in a concentration-dependent manner. The ethanolic and aqueous
extracts of Luffa acutangula showed significant cytotoxic activity in both MTT and SRB assay. In brine shrimp lethality
bioassay also aqueous extract showed more potent cytotoxicity as compared to ethanolic extract