DOI: 10.36347/sajp

Pages: 432-437

A series of 1, 3, 4-thiadiazole derivatives had been synthesized from different Polyhydroxylated aldehydes and ketones. The structures were characterized by IR, 1H NMR and 13C NMR spectral data. The compounds were evaluated for antibacterial activity against gram-positive and gram-negative bacteria. Insilco evaluation was carried, aiming to present potential selective activities as enzyme inhibitors. These activities were suggested by the score values using Molinspiration Cheminformatics program.