DOI: 10.36347/sjams.2016.v04i12.058

Pages: 4493-4498

In the last few decades, abnormality in lipid profile is a serious concern in various diseases including diabetes mellitus. However, limited studies have been documented on lipid abnormality in hypothyroidism (HT) along with diabetes. The objective of present study was to determine the glycemic and lipid profile in nondiabetic and diabetic hypothyroidism patients and to determine their role in disease complexity. Fasting and post prandial blood glucose levels along with serum total cholesterol, triglycerides, HDL, LDL and VLDL levels were estimated by using standard methods in 100 patients of HT divided into two groups of 50 HT nondiabetic patients and 50 HT diabetic patients as Group II and Group III respectively, and compared it with 50 age matched healthy controls (Group I). The values were expressed as Mean ± SD and data from patients and controls were compared using students‘t’ test. Serum total cholesterol, triglycerides, LDL and VLDL levels along with fasting blood sugar were significantly high (p<0.001) and serum HDL levels were significantly low (p<0.001) in Group III patients as compared to control. However, serum total cholesterol, triglycerides, LDL and VLDL levels were altered significantly (p<0.05) in Group II subjects. These finding suggest that diabetic HT patients are at enhanced risk to develop cardiovascular complication due to their altered glycemic and lipid profile with respect to nondiabetic HT patients. Therefore, maintenance of normal thyroid profile, regular monitoring of cardiac markers, control on blood sugar level along with proper treatment of dyslipidemia and diabetes in these patients can prove to be protective.