DOI: 10.36347/sajp

Pages: 463-470

The chemistry of metal complexation containing azo group has been a subject of greater interest in the 21st century. A novel azocalix[4]resorcinarene, 5,11,17,23,tetra methyl calix[4]resorcinarene 1, was prepared by linking 8- aminoquinoline to calix[4]resorcinarene through a diazo-coupling reaction having a conjugated chromophoric azo (- N=N-) group in lower-rim was synthesized by conventional technique. Based on it, a simple, sensitive and selective spectrophotometric method was developed for the determination of Ni2+. This compound in the solid and solution form is elucidated by FT-IR, 1H-NMR, 13C-N MR, as well as elemental analysis technique. Bivalent metal [Copper, Cobalt, and Zinc,Nickel] complexes of azo-calix[4]resorcinarene were synthesized in different molar ratio of metal and ligand in DMSO-Water medium under different pH condition if required. The chemistry of all these complexes is presented here with special attention given to their synthesis, structure, spectral and various other properties. These complexes were studied by UV, IR, TGA, and DTA, techniques. AAS of metal ions reviewed that 4:1 (M : L) complex is established. The stoichiometry of the azo-metal chelates was also determined by the spectroscopic titration method. These complexes have shown slightly increased biological activity on E.coli, B.subtilis, S.aureus and B.megaterium respectively compared to ligand