DOI: 10.36347/sjams.2017.v05i04.016

Pages: 1297-1303

Cirrhosis is a condition in which the liver slowly deteriorates and is unable to function normally due to chronic, or long lasting, injury. Liver biopsy is considered as a gold standard for the diagnosis of cirrhosis and has many problems like bleeding, infective peritonitis which limit use of liver biopsies in all patients. Until date there is no non-invasive marker to replace it. Aim to evaluate the Aspartate aminotransferase-to-platelet ratio index (APRI) as a predictive marker for liver cirrhosis. Material and Methods the present study was analytical cross-sectional study carried out during Aug 2016 to Dec 2016, at Al Khartoum State. A total one hundred individuals were enrolled in this study, and classified into two groups 50 patients with liver cirrhosis diagnosed by ultrasound as case group and 50 healthy individuals as control group. Platelet count and Aspartate aminotransferase (AST) were done using Mindary BC3000 plus hematology analyzer and mindary BA-88A Semi-auto Chemistry Analyzer respectively. APRI was calculated for every patient using the formula {(AST / ULN) x 100}/platelet count (109/L).The Predictive value of APRI was evaluated with a receiver-operating characteristics (ROC) curve. Results the level AST was significantly increased in cirrhosis cases than that in control and the platelet count was significantly lower in cirrhosis cases than that in control, furthermore the APRI level was significantly higher in cirrhosis cases than that in control cases (p-value 0.000, 0.000, 0.000) respectively.