DOI: 10.36347/sjams.2017.v05i05.002

Pages: 1719-1722

To find out the efficacy of intravenous diltiazem, lignocaine and combination of both in reducing the effect on cardiovascular system to laryngoscopy and endotracheal intubation in healthy, ASA PS I and normotensive ASA PS II patients. In this Prospective randomized control study, Patients who are scheduled for total abdominal Hysterectomy, vaginal hysterectomy, laparoscopic Appendectomy, tubectomy and cholecystectomy were divided into four groups, Group 1 received normal saline, Group II received lignocaine 1.5mg/kg, Group III received diltiazem 0.3mg/kg, and Group IV received combination diltiazem 0.3mg/kg and lignocaine 1.5mg/kg. Hemodynamic parameters such as heart rate, systolic and diastolic blood pressure and rate pressure product products are recorded at regular intervals. The data analysis is performed by univariate analysis. The hypothesis is validated by various statistical methods by using statistical packages for social sciences (SPSS 17.0 version). Total 100 patients within age group of 20-50 years were selected for study, 25 in each group, the mean weight in Group I was 53.40±6.17Kgs, in Group II it was 53.40±6.73Kgs, in Group III 52.64±8.164 Kgs and Group IV was 52.96±8.97kgs suggesting mean weight in four groups were comparable. In present study with respect to heart rate, systolic and diastolic blood pressure, mean arterial pressure and rate pressure product there was attenuation all these parameters in all groups but the attenuation was maximum in Group IV followed by Group II and Group III respectively. The data from our study suggests that with combination of both diltiazem and lignocaine is significantly more effective than anyone alone for attenuating hemodynamic changes to laryngoscopy and tracheal intubation in normotensive patients.